[Acyclovir-induced acute renal failure: An under-estimated secondary effect?]. / Insuficiencia renal aguda por aciclovir, un efecto secundario infraestimado?

The increasing use of oral or IV acyclovir to treat infections caused by herpesviridae family involves a rise in the number of observed adverse effects. Neuro- and nephrotoxicity are most serious observed and reported secondary effects. The monitoring of renal function is essential to detect these cases since it develops as a non-oliguric renal failure. Because of this, the outpatient and oral use of the drug can result in an underestimation of the number of cases reported. We report two patients with genital herpes and viral encephalitis that required IV acyclovir. Both inpatients developed an acute renal failure that resolved after the drug was withdrawn.

Insuficiencia renal aguda por aciclovir, ¿un efecto secundario infraestimado? / Acyclovir-induced acute renal failure: an under-estimated secondary effect?

En la actualidad, el mayor uso de aciclovir, por vía intravenosa u oral, para tratar infecciones de la familia Herpesviridae, conlleva un aumento del número de efectos adversos descritos. La neurotoxicidad y nefrotoxicidad son los efectos secundarios más graves que se han comunicado. La monitorización de la función renal es fundamental para detectar estos casos, pues cursa como insuficiencia renal no oligúrica. Por ello, el uso ambulatorio y oral del fármaco puede dar lugar a una infraestimación del número de casos totales. Presentamos los casos de 2 pacientes que por su patología de base (herpes genital y encefalitis viral) precisaron aciclovir intravenoso, y que durante su estancia hospitalaria desarrollaron insuficiencia renal aguda no oligúrica, que cedió al suspender la administración del fármaco

The increasing use of oral or IV acyclovir to treat infections caused by herpesviridae family involves a rise in the number of observed adverse effects. Neuro- and nephrotoxicity are most serious observed and reported secondary effects. The monitoring of renal function is essential to detect these cases since it develops as a non-oliguric renal failure. Because of this, the outpatient and oral use of the drug can result in an underestimation of the number of cases reported. We report two patients with genital herpes and viral encephalitis that required IV acyclovir. Both inpatients developed an acute renal failure that resolved after the drug was withdrawn

Uso profiláctico y terapéutico del ibuprofeno en el cierre del ductus en el recién nacido pretérmino / Prophylactic and therapeutic use of ibuprofen in ductus closure in the preterm newborn

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